Cyclomethicone is a type of silicone commonly used in silicone-based personal lubricant. It is clear, odorless, and smooth, which allows it to work as an effective base in sexual lubricant products.

Cyclomethicone is not directly water-soluble, but washes off with soap and water. It is often combined with dimethicone for longer-lasting lubrication. Like all silicones, cyclomethicone works well with latex condoms but is not recommended for use with silicone toys unless otherwise specified by the manufacturer.