A chemical commonly found in the feverfew plant, a medicinal herb used to treat migraine headaches, infertility, and various other conditions. Parthenol appears to have anti-inflammatory properties, and it is generally well tolerated.

However, people with ragweed allergies may react to feverfew, and pure parthenol may cause nausea or irritation when applied to the skin. Most lubricants and sexual enhancement products use a very limited amount of parthenol and should be safe for everyday use.