A substance made from the root of the peony, a flowering plant popular in alternative medicine. Along with various other parts of the peony, the root is a common folk remedy for various skin conditions, muscle spasms, and a host of other issues.

Peony root extract is sometimes used in lubricant formulas for its potential anti-inflammatory effects. It might also have anti-carcinogenic properties. There is some evidence to show that peony may slow blood clotting, and in large amounts, it may cause uterine contractions; pregnant women should speak with their physicians before using products with this ingredient.